Discovery of autoantibodies against podocyte antigens In the late 1970s, it became evident that podocyte antigens were targeted by the immune system in patients with primary membranous nephropathy (MN), resulting in subepithelial immune complexes and glomerular injury. It was not until 2009, however, that the major antigen target – M-type phospholipase A2 receptor 1 (PLA2R)…