It Takes Two To Tango

The TANGO Consortium (Post-Transplant Glomerular Diseases) is an exciting collaborative effort between patients, physicians, researchers, and industry partners looking at the recurrence of glomerular disease after transplantation

39 Transplant Centers Across 5 Continents

Health Data Collected of Over 1250 Participants

Biorepository With Patient Samples

Why This Research Is Important

Glomerular disease is a condition that affects the glomeruli, the units of the kidney that filter waste and remove extra fluids from the blood. It is the third leading cause of kidney failure in the U.S. and commonly recurs following kidney transplant surgery, shortening the life of the new kidney.

It remains unclear why glomerular disease recurs in some patients, while not in others. Many physicians tried to elucidate this challenging problem within kidney transplant research. Most of these studies were only based on few patients, making it difficult to establish evidence-based clinical guidelines.

We believe collaboration is the only way forward to effectively tackle this rare and challenging disease entity. This is why our team founded the TANGO Consortium, an international network of patients, physicians, researchers, and industry partners that collaborate to study glomerular disease recurrence after kidney transplantation.

What We Do

We obtain health information from glomerular disease patients enabling us to study disease progression and treatment response

We connect patients, scientists, physicians and industry partners with transplant centers across multiple continents to advance this research

We have a biorepository of blood and urine samples of glomerular disease patients, to identify underlying causes of disease, and determine potential novel biomarkers of recurrence

We provide an educational platform for patients with glomerular disease after transplantation

For patients Interested in participating

Any transplant patient with glomerular disease or those on the kidney transplant waitlist, based in the US
How to Join

For Health Care Professionals

Explore our ongoing trials
How to be involved

Learn about Glomerular Disease after Transplant

For transplant patients that want to learn more about recurrent glomerular disease after transplant

Our Team

Leonardo V. Riella, MD, PhD

Principal Investigator

Harvard Medical School, Massachusetts General Hospital, Boston MA

Paolo Cravedi, MD, PhD

Principal Investigator

Icahn School of Medicine at Mount Sinai, New York City, NY

Audrey Uffing, MD

PhD Candidate

Harvard Medical School, Massachusetts General Hospital, Boston MA

Frank Hullekes, MD

PhD Candidate

Harvard Medical School, Massachusetts General Hospital, Boston MA

Rucháma Verhoeff, MD

PhD Candidate

Harvard Medical School, Massachusetts General Hospital, Boston MA

Publications

Recurrence of Membranous Nephropathy after Kidney Transplantation: A Multicenter Retrospective Cohort Study

Authors:
Frank Hullekes, Audrey Uffing, Rucháma Verhoeff, ... , Paolo Cravedi, Leonardo V. Riella

Year of Publication:
2024

Focal Segmental Glomerulosclerosis Recurrence Posttransplant: It Takes Two to TANGO

Authors:
Frank Hullekes, Rucháma Verhoeff, Paolo Cravedi, Leonardo V. Riella

Year of Publication:
2022