Discovery of autoantibodies against podocyte antigens In the late 1970s, it became evident that podocyte antigens were targeted by the immune system in patients with primary membranous nephropathy (MN), resulting in subepithelial immune complexes and glomerular injury. It was not until 2009, however, that the major antigen target – M-type phospholipase A2 receptor 1 (PLA2R)…

In the challenge to find cures for diseases that we face in healthcare, new methods to study disease are continuously being developed, in particular methods that will closely resemble the human biology compared to mouse biology. A recent development that has shown great potential to advance research about human diseases are organoids.   What is…

Most of the studies performed in the field of recurrence of glomerular disease (GD) after transplant are single-center and retrospective, while registry transplant data frequently misclassify the cause of kidney disease. Better estimation of GD incidence post-transplant, natural history and predictors of recurrence are crucial to improve transplant outcomes. Our preliminary database reveals the broad…