In the challenge to find cures for diseases that we face in healthcare, new methods to study disease are continuously being developed, in particular methods that will closely resemble the human biology compared to mouse biology. A recent development that has shown great potential to advance research about human diseases are organoids. What is…
Post-Transplant Glomerular Diseases
WHAT IT IS
The TANGO study is an exciting project, which aims to create a large international
network of centers to study glomerular disease (GN) recurrence after renal transplantation.
Our study protocol was published in BMC Nephrology, click here for more details.
Project goal for summer 2019
BACKGROUND AND SIGNIFICANCE
Kidney transplantation is the ideal treatment for patients with kidney failure. Unfortunately, long-term outcomes are suboptimal. Both understanding the etiologies of chronic allograft injury and providing timely therapeutic interventions are essential to improve allograft survival.
Though post-transplant glomerular disease can be recurrent or de novo, recurrent glomerular disease is the third leading cause of graft loss. While some forms of primary kidney disease are associated with higher risk of recurrence and subsequent early graft loss after transplant, others are associated with a delayed presentation and slower progressive course. Thus far, no clear risk factors have been identified to predict recurrence risk and trials have failed to demonstrate a direct association with the immunosuppression regimens.
Of note, UNOS information frequently misclassifies patients with a diagnosis of glomerular disease, preventing registry analyses to assess disease epidemiology and response to therapy.
INFORMATION FOR PATIENTS
Leonardo V. Riella, MD, PhD
Paolo Cravedi, MD, PhD
Audrey Uffing, MD
Most of the studies performed in the field of recurrence of glomerular disease (GD) after transplant are single-center and retrospective, while registry transplant data frequently misclassify the cause of kidney disease. Better estimation of GD incidence post-transplant, natural history and predictors of recurrence are crucial to improve transplant outcomes. Our preliminary database reveals the broad…